Ichiza lezilwanyana elisebenzayo i-Colistin Sulfate CAS 1264-72-8

Ingcaciso yeMveliso

Ubukhulu becala inefuthe elinamandla lokulwa neebhaktheriya kwiibhaktheriya zegram-negative, kunye neebhaktheriya ezibuthathaka ziquka i-Pseudomonas aeruginosa, i-Escherichia coli, i-Enterobacteria, i-Klebsiella, i-Salmonella, i-Shigella, i-Pasteurella kunye ne-Vibrio. IProteus, Brucella, Serratia kunye nazo zonke iibhaktheriya zeGram-positive zazixhathisa le mveliso.UColistin Sulfatengenxa yokucotha isibulali ntsholongwane, indima ephambili kwiinwebu zeseli yebhaktiriya, xa udityaniswa neebhaktheriya ezibuthathaka, ubume bayo bekhemikhali ye-amino ekhululekileyo (Yang) kunye ne-phosphate ester ye-phosphoric acid ingcambu kwi-membrane yeseli yebhakteria (nge-electronegative), yandisa ukungeneka kwenwebu, ibangela iseli yezinto ezibalulekileyo ezifana ne-amino acids, iingoma zePiao, i-pyrimidine, i-K + yayo.

Aisicelo

Isetyenziselwa ikakhulu ukunyanga izifo zamathumbu ezibangelwa yi-Grame-negative bacilli (Escherichia coli, njl.). Ikwasebenza ngokuchasene nePseudomonas aeruginosa (i-sepsis, usulelo lomjelo womchamo, ukutsha okanye ukosuleleka kwenxeba elibuhlungu).

Iimbonakalo

(1) Inokumelana kakhulu ne-Gram negative bacteria. Ngokukodwa, inempembelelo ethile yophuhliso lwe-Escherichia coli, i-Salmonella, kunye ne-Pseudomonas aeruginosa.

(2) Inefuthe le-bactericidal. Ngokuthintela umsebenzi okhethiweyo wokungena kwiiseli zeseli, iibhaktheriya ziyafa.

(3) Phantse akukho miba yokunganyangeki kweziyobisi. Akukho kumelana ne-R-factor yafunyanwa.

(4) Isebenza nge-synergistically kunye ne-anti Gram positive bacteria bacteria. Xa idibene ne-zinc bacitracin, i-flavomycin, i-sulfonamides, i-penicillin ye-synthetic, i-gentamicin, njl., umphumo ungcono ngakumbi.

(5) Akukho ntsalela. Xa ilawulwa ngomlomo, phantse ayifuntshwa ngamathumbu, kodwa ngexesha lokutofa kwe-intramuscular, ukuqokelela igazi kunye nokufunxa kulungile, ngoko akukho mfuneko yokukhathazeka malunga neentsalela kwiimveliso zezilwanyana.

(6) Ukukhuthaza ukukhula kwemfuyo kunye neenkukhu, kwaye uthintele kwaye ulawule isifo se-enteritis esosulelayo kwimfuyo kunye neenkukhu.