I-β-Triketone Nitisinone Ibulala Iingcongconi Ezingangeni Zibulala Izinambuzane Ngokufunxa Ulusu | Iintsholongwane kunye neeVectors

   Isibulali-zinambuzaneUkuxhathisa phakathi kwe-arthropods ezisasaza izifo ezibalulekileyo kwezolimo, kwezilwanyana nakwimpilo yoluntu kusongela kakhulu iinkqubo zokulawula ii-vector zehlabathi. Izifundo zangaphambili zibonise ukuba ii-arthropod vectors ezifunxa igazi zifumana amazinga aphezulu okufa xa zitya ii-inhibitors ezinegazi ze-4-hydroxyphenylpyruvate dioxygenase (HPPD), i-enzyme yesibini kwi-metabolism ye-tyrosine. Olu phononongo luhlolisise ukusebenza kakuhle kwe-β-triketone HPPD inhibitors nxamnye neentlobo ezisengozini kunye ne-pyrethroid ezixhathisayo zezifo ezintathu eziphambili, kubandakanya iingcongconi ezisasaza izifo zembali ezifana nemalariya, usulelo oluphindaphindayo olufana ne-dengue kunye ne-Zika, kunye neentsholongwane ezisandula ukuvela ezifana neentsholongwane ze-Oropuche kunye ne-Usutu.

Umahluko phakathi kwendlela yokufaka i-topical, i-tarsal kunye ne-vial, iindlela zokufaka, ukuhanjiswa kwezinambuzane kunye nobude bexesha lokusebenza.
Nangona kunjalo, nangona kukho umahluko phakathi kokufa phakathi kweNew Orleans neMuheza kwidosi ephezulu, zonke ezinye iindawo ezixinzelelweyo bezisebenza ngakumbi eNew Orleans (ezinokuchaphazeleka) kunaseMuheza (ezinganyangekiyo) kwiiyure ezingama-24.
Iziphumo zethu zibonisa ukuba i-nitisinone iyabulala iingcongconi ezifunxa igazi ngokunxibelelana ne-transtarsal, ngelixa i-mesotrione, i-sulfotrione, kunye ne-tepoxiton zingayikhethi. Le ndlela yokubulala ayikhethi phakathi kweentlobo zeengcongconi ezibuthathaka okanye ezichasayo kakhulu kwezinye iindidi zezibulali-zinambuzane, kubandakanya i-pyrethroids, i-organochlorines, kwaye mhlawumbi ne-carbamates. Ngaphezu koko, ukusebenza kwe-nitisinone ekubulaleni iingcongconi ngokufunxa i-epidermal akupheleli kwiintlobo ze-Anopheles, njengoko kuboniswe kukusebenza kwayo ngokuchasene ne-Strongyloides quinquefasciatus kunye ne-Aedes aegypti. Idatha yethu ixhasa isidingo sophando olongezelelweyo lokuphucula ukufunxa i-nitisinone, mhlawumbi ngokuphucula iikhemikhali zokufunxa i-epidermal okanye ukongezwa kwee-adjuvants. Ngendlela yayo entsha yokusebenza, i-nitisinone isebenzisa indlela yokufunxa igazi yeengcongconi ezingamabhinqa. Oku kuyenza ibe ngumviwa othembisayo kwiispreyi ezisele zangaphakathi ezintsha kunye ne-inethi zokubulala izinambuzane ezihlala ixesha elide, ngakumbi kwimimandla apho iindlela zemveli zokulawula iingcongconi zingasebenzi ngenxa yokuvela ngokukhawuleza kokuxhathisa i-pyrethroid.