I-β-Triketone I-Nitisinone Ibulala Iingcongconi Ezikwaziyo Ukubulala Izinambuzane Ngokufunxa ulusu | IiParasites kunye neeVectors

   Isibulali zinambuzaneukunganyangeki phakathi kwee-arthropods ezisasaza izifo ezibaluleke kakhulu kwezolimo, kunyango lwezilwanyana kunye nezempilo yoluntu kubeka isoyikiso esibi kakhulu kwiinkqubo zolawulo lwehlabathi. Uphononongo lwangaphambili lubonise ukuba ii-arthropod vectors ezifunxa igazi zifumana amazinga aphezulu okufa xa kutyiwa igazi eline-inhibitors ye-4-hydroxyphenylpyruvate dioxygenase (HPPD), i-enzyme yesibini kwi-tyrosine metabolism. Olu phononongo luvavanye ukusebenza kwe-β-triketone HPPD inhibitors ngokuchasene neentlobo ezinokuthi zenzeke kunye ne-pyrethroid-resistant zezifo ezintathu eziphambili zezifo, kubandakanywa iingcongconi ezihambisa izifo zembali ezifana ne-malaria, izifo eziphindaphindiweyo ezifana ne-dengue kunye ne-Zika, kunye neentsholongwane ezikhulayo ezifana ne-Oropuche kunye ne-Usutu virus.

Umahluko phakathi kweendlela ze-topical, i-tarsal kunye ne-vial, iindlela zokusetyenziswa, ukuhanjiswa kwe-insecticide kunye nobude besenzo.
Nangona kunjalo, nangona umehluko wokufa phakathi kweNew Orleans kunye ne-Muheza kwi-dose ephezulu, zonke ezinye izinto ezigxininisiweyo zazisebenza ngakumbi eNew Orleans (ezithintekayo) kune-Muheza (i-resistant) ngaphezu kweeyure ze-24.
Iziphumo zethu zibonisa ukuba i-nitisinone ibulala iingcongconi ezifunxa igazi nge-transtarsal contact, kanti i-mesotrione, i-sulfotrione, kunye ne-tepoxiton ayenzi. Le ndlela yokubulala ayicaluli phakathi kweentlobo zeengcongconi ezinovakalelo okanye ezixhathisa kakhulu kwezinye iindidi zezinambuzane, kuquka i-pyrethroids, i-organochlorines, kwaye mhlawumbi i-carbamates. Ngaphaya koko, ukusebenza kwe-nitisinone ekubulaleni iingcongconi ngokufunxa i-epidermal akupheleliselwanga kwiintlobo ze-Anopheles, njengoko kubonisiwe ngokusebenza kwayo ngokuchasene ne-Strongyloides quinquefasciatus kunye ne-Aedes aegypti. Idatha yethu ixhasa imfuno yophando oluthe kratya lokwandisa ukufunxwa kwe-nitisinone, mhlawumbi ngokuphucula imichiza yokufunxa i-epidermal okanye ukongezwa kwezincedisi. Ngendlela yayo entsha yokwenza, i-nitisinone isebenzisa indlela yokuziphatha yokufunxa igazi kwiingcongconi zabasetyhini. Oku kuyenza ibe ngumgqatswa othembisayo kwizitshizi zentsalela yangaphakathi kunye nenethi ehlala ixesha elide yokubulala izinambuzane, ngakumbi kwimimandla apho iindlela zokulawula iingcongconi zemveli zingasebenziyo ngenxa yokuvela ngokukhawuleza kokuxhathisa kwepyrethroid.