Ukuchanabeka kwi-pyrethroids kunokunyusa umngcipheko wesifo sikaParkinson ngenxa yokusebenzisana nemfuza ngenkqubo yomzimba yokuzikhusela.
Iipyrethroids zifumaneka kwiindawo ezininzi zorhweboizibulali-zinambuzane zasekhayaNangona ziyingozi kwimithambo-luvo kwizinambuzane, ngokubanzi zithathwa njengezikhuselekileyo ukuba zingadibani nabantu ziingcali zikarhulumente.
Ukwahluka kwemfuza kunye nokuvezwa kwezibulali-zinambuzane kubonakala ngathi kunefuthe kwingozi yesifo sikaParkinson. Uphononongo olutsha lufumene unxibelelwano phakathi kwezi zinto zimbini zomngcipheko, lugxininisa indima yempendulo yomzimba ekuqhubekeni kwesifo.
Ezi ziphumo zinxulumene nodidi lweizibulali-zinambuzaneezibizwa ngokuba zii-pyrethroids, ezifumaneka kwiintlobo ezininzi zezibulali-zinambuzane zasekhaya zorhwebo kwaye zisetyenziswa kakhulu kwezolimo njengoko ezinye izibulali-zinambuzane zisuswa. Nangona ii-pyrethroids ziyingozi kwizinambuzane, oorhulumente bakarhulumente ngokubanzi bazijonga njengezikhuselekileyo ekuchaphazelekeni ngabantu.
Olu phononongo lolokuqala ukunxulumanisa ukuvezwa kwe-pyrethroid kumngcipheko wemfuza wesifo sikaParkinson kwaye lufuna uphando olulandelayo, utshilo umbhali oyintloko uMalu Tansi, Ph.D., uprofesa oncedisayo we-physiology kwiSikolo sezonyango seYunivesithi yase-Emory.
Uhlobo lwemfuza olufunyenwe liqela lukwindawo engabhalwanga ikhowudi ye-MHC II (major histocompatibility complex class II) genes, iqela lee-genes ezilawula inkqubo yomzimba yokuzikhusela.
“Besingalindelanga ukufumana ikhonkco elithile kwi-pyrethroids,” utshilo uTansey. “Kuyaziwa ukuba ukuchatshazelwa ngokukhawuleza yi-pyrethroids kunokubangela ukungasebenzi kakuhle komzimba, kwaye iimolekyuli ezisebenza kuzo zinokufumaneka kwiiseli zomzimba; Ngoku kufuneka siqonde ngakumbi malunga nendlela ukuchatshazelwa ixesha elide okuchaphazela ngayo inkqubo yomzimba yokuzikhusela kwaye ngaloo ndlela kuphucula ukusebenza kwayo.” Umngcipheko wesifo sikaKinson.”
“Sele kukho ubungqina obuqinileyo bokuba ukudumba kobuchopho okanye inkqubo yomzimba yokuzikhusela esebenza kakhulu inokuba negalelo ekuqhubekeni kwesifo sikaParkinson. “Sicinga ukuba okunokwenzeka apha kukuba ukuchatshazelwa yimeko-bume kunokutshintsha indlela umzimba osabela ngayo kwabanye abantu, nto leyo ekhuthaza ukudumba okungapheliyo engqondweni.”
Kolu phando, abaphandi base-Emory abakhokelwa nguTansey kunye noJeremy Boss, Ph.D., usihlalo weSebe leMicrobiology kunye ne-Immunology, badibene noStuart Factor, Ph.D., umlawuli weZiko leSifo sikaParkinson sika-Emory, kunye noBeate Ritz., MD, kwiYunivesithi yaseCalifornia, eSan Francisco. Ngokubambisana nabaphandi bezempilo yoluntu e-UCLA, Ph.D. Umbhali wokuqala weli nqaku nguGeorge T. Kannarkat, MD.
Abaphandi be-UCLA basebenzise isiseko sedatha saseCalifornia esigubungela iminyaka engama-30 yokusetyenziswa kwezibulali-zinambuzane kwezolimo. Bafumanise ukuba ziyachaphazeleka ngokusekwe kumgama (idilesi yomsebenzi womntu kunye neyasekhaya) kodwa abazange balinganise amanqanaba ezibulali-zinambuzane emzimbeni. Kukholelwa ukuba ii-pyrethroids ziyawohloka ngokukhawuleza, ingakumbi xa zichatshazelwa lilanga, kwaye zihlala iintsuku ukuya kwiiveki.
Phakathi kwabantu abayi-962 abavela kwiCentral Valley yaseCalifornia, uhlobo oluqhelekileyo lwe-MHC II oludityaniswe nokuchatshazelwa ngaphezu komndilili kwi-pyrethroid pesticides kwandisa umngcipheko wesifo sikaParkinson. Uhlobo oluyingozi kakhulu lwe-gene (abantu abane-alleles ezimbini ezinobungozi) lufunyenwe kwi-21% yezigulane ezine-Parkinson's disease kunye ne-16% yabalawuli.
Kweli qela, ukuchatshazelwa yijini okanye i-pyrethroid yodwa akuzange konyuse kakhulu umngcipheko wesifo sikaParkinson, kodwa indibaniselwano yayo yenza njalo. Xa kuthelekiswa nomndilili, abantu ababechatshazelwe yi-pyrethroid kwaye babenohlobo oluphezulu lomngcipheko wejini ye-MHC II babenomngcipheko ophindwe ka-2.48 wokufumana isifo sikaParkinson kunabo babechatshazelwe kancinci kwaye babenohlobo oluphantsi lomngcipheko wejini. Ukuchatshazelwa kwezinye iintlobo zezibulali zinambuzane, ezifana ne-organophosphates okanye i-paraquat, akonyusi umngcipheko ngendlela efanayo.
Izifundo ezinkulu zemfuza, kuquka uFactor kunye nezigulane zakhe, ngaphambili bezinxibelelanisa umahluko wemfuza ye-MHC II nesifo sikaParkinson. Okumangalisayo kukuba, umahluko ofanayo wemfuza uchaphazela umngcipheko wesifo sikaParkinson ngokwahlukileyo kubantu baseCaucasian/Europe kunye nabantu baseTshayina. Imfuza ye-MHC II yahluka kakhulu phakathi kwabantu; ke ngoko, idlala indima ebalulekileyo ekukhetheni ukufakelwa kwamalungu omzimba.
Ezinye iimvavanyo zibonise ukuba ukwahluka kwezakhi zofuzo okunxulunyaniswa nesifo sikaParkinson kunxulumene nokusebenza kweeseli zomzimba. Abaphandi bafumanise ukuba phakathi kwezigulane ezingama-81 zesifo sikaParkinson kunye nabalawuli baseYurophu abavela kwiYunivesithi yase-Emory, iiseli zomzimba ezivela kubantu abanezakhi zofuzo ze-MHC II ezinobungozi obukhulu ezivela kuphando lwaseCalifornia zibonise iimolekyuli ze-MHC ezingaphezulu.
Iimolekyuli zeMHC zisisiseko senkqubo "yokubonakaliswa kwe-antigen" kwaye zingamandla aqhubayo avuselela iiseli ze-T kwaye abandakanye lonke inkqubo yomzimba yokuzikhusela. Ukubonakaliswa kweMHC II kuyanda kwiiseli ezithuleyo zezigulane zesifo sikaParkinson kunye nabalawuli abasempilweni, kodwa impendulo enkulu kwimingeni yomzimba yokuzikhusela ibonwa kwizigulane zesifo sikaParkinson ezinee-genotypes ezinobungozi obukhulu;
Ababhali bagqibe ngelithi: “Idatha yethu ibonisa ukuba ii-biomarkers zeseli, ezifana nokusebenza kwe-MHC II, zinokuba luncedo ngakumbi kunee-molecule ezinyibilikayo kwi-plasma kunye nolwelo lwe-cerebrospinal ekuchongeni abantu abasengozini yesifo okanye ekuqesheni izigulana ukuba zithathe inxaxheba kuvavanyo lwamayeza okuguqula amasosha omzimba.” “Uvavanyo.”
Olu phononongo luxhaswe yiNational Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), iNational Institute of Environmental Health Sciences (5P01ES016731), iNational Institute of General Medical Sciences (GM47310), iSartain Lanier Family Foundation, kunye neMichael J. Foxpa Kingson Foundation for Disease Research.
Ixesha lokuthumela: Juni-04-2024