Ukuvezwa kwi-pyrethroids kunokonyusa umngcipheko wesifo sikaParkinson ngenxa yokunxibelelana nemfuzo ngamajoni omzimba.
Iipyrethroids zifumaneka kwiindawo ezininzi zorhweboimichiza yasekhaya.Nangona ziyi-neurotoxic kwizinambuzane, zibonwa njengekhuselekile kunxibelelwano lwabantu ngabasemagunyeni bomanyano.
Ukwahluka kwemfuza kunye nokuvezwa kwezibulali zinambuzane kubonakala kuchaphazela umngcipheko wesifo sikaParkinson.Uphononongo olutsha lufumana unxibelelwano phakathi kwezi zinto zimbini zomngcipheko, ziqaqambisa indima yokusabela komzimba kwinkqubela phambili yesifo.
Iziphumo zinxulumene neklasi yeizibulali zinambuzaneebizwa ngokuba zii-pyrethroids, ezifumaneka kuninzi lwezitshabalalisi zasekhaya zorhwebo kwaye zisetyenziswa kakhulu kwezolimo njengoko ezinye izibulali-zinambuzane zipheliswa.Nangona i-pyrethroids iyi-neurotoxic kwizinambuzane, abasemagunyeni bomdibaniso bazijonga njengekhuselekile ekuvezweni kwabantu.
Uphononongo lolokuqala ukudibanisa ukuvezwa kwe-pyrethroid kwingozi yemfuza yesifo sika-Parkinson kunye neziqinisekiso zokulandelela izifundo, utshilo umbhali ophakamileyo uMalu Tansi, Ph.D., uprofesa oncedisayo we-physiology kwi-Emory University School of Medicine.
Ukwahluka kofuzo iqela elifunyenweyo likummandla ongeyiyo ikhowudi ye-MHC II (iklasi enkulu ye-histocompatibility complex II), iqela leejeni ezilawula amajoni omzimba.
“Besingalindelanga ukufumana ikhonkco elithile le-pyrethroids,” utshilo uTansey.“Kuyaziwa ukuba ukuchanabeka kabukhali kwipyrethroids kunokubangela ukungasebenzi kakuhle kwamajoni omzimba, yaye iimolekyuli ezisebenza kuzo zinokufunyanwa kwiiseli zomzimba;Ngoku kufuneka siqonde ngakumbi malunga nokuba ukuvezwa kwexesha elide kuyichaphazela njani inkqubo yokhuselo lomzimba kwaye ngaloo ndlela iphucula umsebenzi wayo. ”Umngcipheko wesifo sikaKinson. ”
“Sele kukho ubungqina obunamandla bokuba ukudumba kwengqondo okanye ukusebenza ngokugqithisileyo kwenkqubo yomzimba yokuzikhusela kunokubangela ukuba isifo sikaParkinson siqhubeke."Sicinga ukuba kungenzeka ntoni apha kukuba ukuvezwa kwendalo kunokutshintsha impendulo yokuzikhusela kwabanye abantu, ukukhuthaza ukudumba okungapheliyo engqondweni."
Kwisifundo, abaphandi baka-Emory abakhokelwa nguTansey noJeremy Boss, Ph.D., usihlalo weSebe leMicrobiology kunye ne-Immunology, bahlangene noStuart Factor, Ph.D., umlawuli we-Emory's Comprehensive Parkinson's Disease Centre, kunye noBeate Ritz., MD, kwiYunivesithi yaseCalifornia, eSan Francisco.Ngentsebenziswano nabaphandi bempilo yoluntu kwi-UCLA, Ph.D.Umbhali wokuqala wenqaku nguGeorge T. Kannarkat, MD.
Abaphandi base-UCLA basebenzise isiseko sedatha saseCalifornia esiquka iminyaka engama-30 yokusetyenziswa kwezibulali zinambuzane kwezolimo.Baye bamisela ukuvezwa okusekwe kumgama (umsebenzi womntu kunye needilesi zasekhaya) kodwa khange balinganise amanqanaba ezitshabalalisi emzimbeni.I-Pyrethroids icingelwa ukuba iyancipha ngokukhawuleza, ngakumbi xa ibonakaliswe elangeni, kunye nesiqingatha sobomi emhlabeni weentsuku ukuya kwiiveki.
Phakathi kwezifundo ze-962 ezivela kwi-Central Valley yaseCalifornia, ukwahluka okuqhelekileyo kwe-MHC II kudityaniswe nokuvezwa okungaphezulu kwe-avareji kwi-pyrethroid pesticides kwandisa ingozi yesifo sika-Parkinson.Uhlobo oluyingozi kakhulu lwejini (abantu abaphethe ii-alleles ezimbini zomngcipheko) bafunyenwe kwi-21% yezigulane ezine-Parkinson's disease kunye ne-16% yokulawula.
Kweli qela, ukuvezwa kwi-gene okanye i-pyrethroid yodwa ayizange inyuse kakhulu ingozi yesifo sika-Parkinson, kodwa indibaniselwano yenza.Xa kuthelekiswa ne-avareji, abantu abaye bavezwa kwi-pyrethroids kwaye bathwala uhlobo oluphezulu lwengozi ye-MHC II yemfuza babenomngcipheko we-2.48 wamaxesha amaninzi okuba nesifo sika-Parkinson kunabo banokungakhuselekanga okuncinci kwaye baphathe uhlobo oluphantsi lomngcipheko we-gene.ingozi.Ukuvezwa kwezinye iintlobo ze-pesticides, ezifana ne-organophosphates okanye i-paraquat, ayinyusi ingozi ngendlela efanayo.
Izifundo ezinkulu zofuzo, ezibandakanya i-Factor kunye nezigulane zakhe, ziye zadibanisa ngaphambili iinguqu ze-MHC II kwi-Parkinson's disease.Okumangalisayo kukuba, ukwahluka okufanayo kofuzo kuchaphazela umngcipheko wesifo sikaParkinson ngokwahlukileyo kubantu baseCaucasians / baseYurophu kunye nabantu baseTshayina.Iijini ze-MHC II ziyahluka kakhulu phakathi kwabantu;ngoko ke, badlala indima ebalulekileyo ekukhetheni ukutshintshwa kwamalungu.
Olunye uvavanyo lubonise ukuba ukuguquguquka kofuzo okuhambelana nesifo sikaParkinson kuhambelana nokusebenza kweeseli zomzimba.Abaphandi bafumanisa ukuba phakathi kwezigulane ze-81 ze-Parkinson kunye nokulawulwa kweYurophu kwiYunivesithi yase-Emory, iiseli zomzimba ezivela kubantu abanomngcipheko ophezulu we-MHC II ezahlukeneyo zofuzo ezivela kuphononongo lwaseCalifornia zibonise iimolekyuli ezininzi ze-MHC.
Iimolekyuli ze-MHC ziphantsi kwenkqubo "ye-antigen presentation" kwaye ingamandla aqhubayo okwenza iiseli ze-T zisebenze kwaye zibandakanye onke amajoni omzimba.Ukubonakaliswa kwe-MHC II kwandiswe kwiiseli ezipholileyo zezigulane ze-Parkinson kunye nokulawulwa okunempilo, kodwa impendulo enkulu kumngeni we-immune ibonakala kwizigulane ze-Parkinson ezine-genotypes ezinobungozi obukhulu;
Ababhali baqukumbela ngelithi: "Idatha yethu icebisa ukuba ii-biomarkers zeselula, ezinje ngokusebenza kwe-MHC II, zinokuba luncedo ngakumbi kuneamolekyuli ezinyibilikayo kwiplasma kunye ne-cerebrospinal fluid ukuchonga abantu abasengozini yesifo okanye ukukhangela abaguli ukuba bathathe inxaxheba kwiimvavanyo ze-immunomodulatory drugs.""Uvavanyo."
Uphononongo luxhaswe yiNational Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), iNational Institute of Environmental Health Sciences (5P01ES016731), iNational Institute of General Medical Sciences (GM47310), iSartain Foundation, kunye neSartain Foundation. uMichael J. Foxpa Kingson Foundation yoPhando lweZifo.
Ixesha lokuposa: Jun-04-2024