Inguquko yexeshana yokunganyangeki kwezinambuzane kunye nebhayoloji yezona ntsholongwane ziphambili zemalariya, iingcongconi ze-Anopheles, eUganda

Ukwandisaisibulali zinambuzaneukumelana kunciphisa ukusebenza kolawulo lwe-vector. Ukubeka iliso ukumelana ne-vector kubalulekile ukuqonda ukuvela kwayo kunye nokuyila iimpendulo ezisebenzayo. Kolu phononongo, sibeke iliso kwiipateni zokuxhathisa amayeza ezinambuzane, i-vector population biology, kunye nokwahluka kofuzo okunxulunyaniswa nokuxhathisa e-Uganda kwisithuba seminyaka emithathu ukusuka ku-2021 ukuya ku-2023. E-Mayuga, i-Anopheles funestus ss yayiyeyona ntlobo ibalaseleyo, kodwa bekukho ubungqina bokuxutywa nezinye ii-An. iintlobo ze-funestus. I-Sporozoite infestation yayiphezulu kakhulu, ifikelela kwi-20.41% ngo-Matshi 2022. Ukuxhatshazwa okunamandla kwabonwa kwi-pyrethroids ngamaxesha e-10 yoxinaniso lokuxilonga, kodwa ukuchaphazeleka kwafunyanwa ngokuyinxenye kuvavanyo lwe-PBO synergy.
Imephu yeendawo zokuqokelelwa kweengcongconi kwiSithili saseMayuge. ISithili saseMayuge siboniswe ngombala omdaka. Iidolophana apho uqokelelo lwenziwa khona ziphawulwe ngeenkwenkwezi eziluhlaza. Le mephu yenziwe kusetyenziswa isoftware ye-QGIS yasimahla nevulelekileyo 3.38.
Zonke iingcongconi zagcinwa phantsi kweemeko eziqhelekileyo zokukhuliswa kweengcongconi: 24-28 °C, 65-85% yokufuma okuhambelanayo, kunye nexesha lendalo le-12:12 lemini. Imibungu yeengcongconi yayikhuliswe kwiitreyi zombungu kwaye yondliwe i-tetramine ad libitum. Amanzi ombungu ayetshintshwa rhoqo emva kweentsuku ezintathu de aphume. Abantu abadala abakhulayo bagcinwe kwiikheji ze-Bugdom kwaye zondliwe isisombululo seswekile se-10% kwiintsuku ze-3-5 ngaphambi kwe-bioassay.
Ukusweleka kwi-pyrethroid bioassay kwinqanaba le-F1. Ukusweleka kwamabala eengcongconi ze-Anopheles ezisesichengeni kwi-pyrethroids kuphela kunye nakwi-pyrethroids zidityaniswe ne-synergists. Imivalo yempazamo kwibar kunye neetshathi zekholomu zimelela amaxesha okuzithemba ngokusekelwe kwimpazamo esemgangathweni yentsingiselo (SEM), kwaye i-NA ibonisa ukuba uvavanyo aluzange lwenziwe. Umgca obomvu onamachaphaza onqamlezileyo ubonisa i-90% yezinga lokufa ngaphantsi apho ukuchasana kuqinisekisiwe.
Zonke iiseti zedatha ezenziwe okanye ezihlalutyiweyo ngexesha lolu phononongo zibandakanyiwe kwinqaku elipapashwe kunye neefayile zoLwazi oloNgezelelweyo.
Inguqulelo yokuqala ye-intanethi yeli nqaku ilungisiwe: Inguqulelo yokuqala yeli nqaku yapapashwa ngempazamo phantsi kwelayisensi ye-CC BY-NC-ND. Ilayisenisi iye yalungiswa yaba yiCC BY.