Isifo sokuphefumla kwehagu besisoloko sisigulo esinzima esithwaxa abanini beefama zeehagu. I-etiology inzima, ii-pathogens zahlukene, ukuxhaphaka kubanzi, kwaye ukuthintela kunye nokulawula kunzima, okuzisa ilahleko enkulu kwiifama zehagu. Kwiminyaka yakutshanje, izifo zokuphefumla kwifama yehagu zihlala zibonakalisa izifo ezixubeneyo, ngoko ke siqhele ukuyibiza ngokuba yi-pig farm breathing syndrome. Iintsholongwane eziqhelekileyo ziquka iMycoplasma, Haemophilus parasuis, Actinobacillus pleuropneumoniae, indlebe eluhlaza, i-circovirus kunye nomkhuhlane wehagu.
Ukuthintela kunye nokunyangwa kwezifo zokuphefumula, i-tilmicosin inefuthe elihle
Iintsholongwane zokuphefumla kweehagu zohlulwe kakhulu zibe ziintsholongwane, iintsholongwane kunye ne-mycoplasma. Kwi-mycoplasma kunye ne-porcine infectious pleuropneumonia, i-antibiotics yesiqhelo yangoku iye yavelisa ukuxhathisa, kwaye isizukulwana esitsha se-antibiotics samkelwa ngokubanzi kwiklinikhi ukukhusela kunye nokunyanga izifo zokuphefumula kweehagu. Ngokomzekelo, i-tilmicosin, i-doxycycline, i-tyvalomycin, njl., kunye neyeza zendabuko zaseShayina, zinempembelelo enkulu. Uphononongo lubonise ukuba i-tilmicosin ineempembelelo ze-antiviral inxalenye, kwaye inefuthe elihle ekulawuleni i-porcine ye-syndrome yesifo sokuphefumula esihambelana ne-porcine PRRS.
I-Tilmicosininenkqubo enzulu kwaye ineenzuzo ezininzi zokwaleka kabini.
Njengoko sisazi sonke, i-tilmicosin lelinye lamachiza asebenzayo okulawula izifo zokuphefumla kwiifama zeehagu. Nangona kunjalo, iziphumo ezahlukeneyo ze-tilmicosin kwimarike azilingani. Kutheni kunje? Sinokwahlula njani phakathi kwazo? Kuthekani ngomahluko? Kwi-tilmicosin, izinto eziluhlaza ziphantse zifane, kwaye akukho mahluko kakhulu. Ukubonakalisa umphumo wemveliso, ngokuyinhloko kuxhomekeke kwinkqubo yokuvelisa. Kwinkqubo yokwenziwa kwemveliso, ukuzabalazela isiphumo esingcono semveliso kuye kwaba yeyona nto iphambili. indlela yophuhliso.
Umgangatho ophezulutilmicosinkufuneka ibeneempawu ezine: iihagu ziyathanda ukutya, ukukhuselwa kwesisu, ukunyibilika kwamathumbu kunye nokuphuma kancinci.
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Ukwahlula kwinkangeleko
1. Iingqungquthela ze-tilmicosin ezingabonakaliyo zihle kakhulu kwaye zilula ukunyibilika kwiqondo lokushisa, ngelixa i-tilmicosin i-coated particles inzima kwaye inzima ukuyichitha kwiqondo lokushisa.
2. I-tilmicosin enhle (efana ne-Chuankexin efakwe kwi-microcapsules ye-double-layer) ineengqungquthela ezifanayo kunye neengqungquthela. Ngokubanzi, amasuntswana e-tilmicosin coated ayahluka ngobukhulu kunye nokufana.
Ukwahlula kwincasa emlonyeni (incasa entle)
I-Tilmicosinincasa ekrakra, kwaye i-tilmicosin engafakwanga ayifanelekanga ukulawulwa ngomlomo. I-Tilmicosin enencasa ekrakra emlonyeni ayiphumeleli kuphela ukuxinana kweziyobisi ezingafunekiyo, kodwa ikwachaphazela kakhulu ukutya kweehagu kwaye ibangela umonakalo omkhulu. Inkunkuma yeziyobisi.
Ukwahlula kwi-solubility yesisu kunye ne-enteric solubility
1. Ukugquma kwe-tilmicosin kwahlulwe kwi-enteric (i-asidi-resistant kodwa i-alkali-resistant) yokugquma kunye ne-gastric-soluble (kungekhona i-acid- kunye ne-alkali-resistant). I-gastric-soluble (enganyangekiyo kwi-asidi kunye ne-alkali) egqunywe i-tilmicosin iya kunyibilika kwaye ikhutshwe yi-asidi yesisu esiswini, kwaye xa ichiza likhutshwe, liya kuvuselela i-gastric mucosa ukuba ikhuphe incindi yesisu, kunye nejusi yesisu ngokugqithiseleyo kunokubangela ukopha kwesisu kunye nezilonda zesisu. Ukuba ichiza lichithwe esiswini kwaye likhutshwe kwangaphambili, i-bioavailability yechiza nayo iya kuncitshiswa kakhulu. Ngokuqhelekileyo, ukusebenza kwechiza elinyibilikisiweyo esiswini kuya kuncitshiswa ngaphezu kwe-10% xa kuthelekiswa naloo emathunjini. Oku konyusa kakhulu iindleko zamayeza.
2. Ukugquma kwe-Enteric (i-anti-asidi kodwa ingekho i-alkali) Ukugquma kunganyibilika kwaye kukhutshwe nge-gastric acid environment enganyibilikiyo kwindawo ye-alkaline yamathumbu, ukuthintela iziphumo ezahlukeneyo zecala kunye neempendulo ze-cardiotoxic ezibangelwa ukukhululwa kwangaphambili kwisisu. Ngelo xesha, i-bioavailability yeziyobisi emathunjini iphuculwe. Ukukhutshwa ngokukhawuleza emathunjini.
I-enteric coating isebenzisa izinto ezahlukeneyo zokugquma kunye neenkqubo, kunye nokusebenza kakuhle kokukhululwa emathunjini kukwahluke. Ukutya okuqhelekileyo kuchithwa ngokuyinxenye kwaye kukhutshwe kwisigxina sesisu kunye nesisombululo sesisu, esahluke kakhulu kwisiphumo se-double-layer microcapsule coating, kunye nesantya sokufunxa kwi-intestinal tract.
Ixesha lokuposa: Mar-17-2022