Florfenicolsisibulala-zintsholongwane esibanzi, esinesiphumo esihle sokuthintela kwiibhaktheriya zeGram-positive kunye neebhaktheriya ezingalunganga.Ngoko ke, iifama ezininzi zeehagu zihlala zisebenzisa i-florfenicol ukuthintela okanye ukunyanga iihagu kwimeko yezifo ezihlala rhoqo.abagulayo.Abasebenzi bonyango lwezilwanyana kwezinye iifama zeehagu basebenzisa idosi ephezulu yeflorfenicol ukunyanga okanye ukuthintela izifo nokuba sisiphi isifo, nokuba liphi iqela okanye inqanaba.I-Flofenicol ayikho i-panacea, kwaye kufuneka isetyenziswe ngokufanelekileyo ukufezekisa umphumo oyifunayo.Apha ngezantsi sazisa ingqiqo yokusetyenziswa kweflorfenicol ngokweenkcukacha, ngethemba lokuba iya kuba luncedo kuninzi lwamafama ehagu:
1. Iipropati ze-Antibacterial zeiflorfenicol
1. Ine-antibacterial spectrum ebanzi kakhulu, kwaye inefuthe elinamandla lokubulala kwiibhaktheriya ze-Gram-positive kunye neebhaktheriya ezimbi, kunye neebhaktheriya ze-anaerobic ze-Gram kunye ne-spirochetes engathandekiyo, i-rickettsia, i-amoeba, njl.
2. Iimvavanyo ze-in vitro kunye ne-vivo zibonisa ukuba umsebenzi wayo we-antibacterial ungcono kakhulu kunamachiza akhoyo ngoku.
3. Ukukhawuleza, i-florfenicol inokufikelela kwi-concentration yonyango kwi-1 iyure emva kwe-injection ye-intramuscular, kunye ne-peak concentration yeziyobisi inokufikelela kwiiyure ze-1.5-3;ixesha elide, ukuxinwa kweyeza legazi elisebenzayo kunokugcinwa ngaphezu kweeyure ezingama-20 emva kolawulo olunye.
4. Inokungena kumqobo wegazi-ingqondo, kwaye umphumo wayo wonyango kwi-meningitis ye-bacteria yezilwanyana ayinakuthelekiswa namanye amachiza e-antibacterial.
5. Ayinayo ityhefu kunye nemiphumo emibi xa isetyenziswe kwisixa esicetyiswayo, inqoba ingozi ye-aplastic anemia kunye nezinye i-toxicity ebangelwa yi-thiamphenicol, kwaye ayibangeli ingozi kwizilwanyana kunye nokutya.Isetyenziselwa ukosuleleka kwamalungu ahlukeneyo omzimba okubangelwa yintsholongwane kwizilwanyana.Unyango, kubandakanywa uthintelo kunye nokunyangwa kwezifo zokuphefumla kwebhaktheriya, i-meningitis, i-pleurisy, i-mastitis, izifo zamathumbu kunye ne-postpartum syndrome kwiihagu.
2. Iibhaktheriya ezithintekayo zeiflorfenicol
1. Izifo zehagu apho iflorfenicol ikhethwa khona
Le mveliso iyacetyiswa njengechiza elikhethiweyo lenyumoniya yehagu, i-porcine infectious pleuropneumonia kunye nesifo se-Haemophilus parasuis, ngakumbi kunyango lweebhaktheriya ezichasene ne-fluoroquinolones kunye nezinye izibulala-ntsholongwane.
2. IFlorfenicol ingasetyenziselwa ukunyanga ezi zifo zehagu zilandelayo
Ingasetyenziselwa ukunyanga izifo zokuphefumula ezibangelwa yi-Streptococcus (inyumoniya), i-Bordetella bronchiseptica (i-atrophic rhinitis), i-Mycoplasma pneumoniae (i-asthma yehagu), njl.;i-salmonellosis (i-piglet paratyphoid), i-colibacillosis (i-piglet asthma) Izifo zomgudu wokugaya ukutya ezifana ne-enteritis ebangelwa lurhudo olutyheli, utyatyazo olumhlophe, isifo se-piglet edema) kunye nezinye iibhaktheriya ezibuthathaka.I-Flofenicol ingasetyenziselwa ukunyangwa kwezi zifo zehagu, kodwa akusiyo isilwanyana esikhethiweyo kwezi zifo zeehagu, ngoko kufuneka zisetyenziswe ngononophelo.
3. Ukusetyenziswa ngokungafanelekanga kweiflorfenicol
1. Idosi inkulu kakhulu okanye incinci kakhulu.Iidosi ezinkulu zinetyhefu, kwaye iidosi ezincinci azisebenzi..
2. ixesha lide kakhulu.Usetyenziso lwexesha elide lwedosi ephezulu yamachiza ngaphandle kokuthintelwa.
3.ukusetyenziswa kwezinto, iimpazamo zeqonga.Iihagu ezikhulelweyo kunye neehagu ezityebileyo zisebenzisa amayeza anjalo ngokungakhethiyo, abangela ityhefu okanye iintsalela zeziyobisi, okukhokelela kwimveliso engakhuselekanga kunye nokutya.
4. Ukuhambelana okungafanelekanga.Abanye abantu bahlala besebenzisa i-florfenicol ngokudibanisa ne-sulfonamides kunye ne-cephalosporins.Ukuba isayensi kwaye isengqiqweni kufanelekile ukuphononongwa.
5. Ukutya okuxutyiweyo akuxutywanga ngokulinganayo, okubangela ukuba akukho siphumo seyeza okanye ityhefu yeziyobisi.
Okwesine, ukusetyenziswa kweiflorfenicolukulumkela
1. Le mveliso akufanele isetyenziswe ngokudibanisa ne-macrolides, i-lincosamides kunye ne-diterpenoid semi-synthetic antibiotics - i-Tiamulin, enokuvelisa imiphumo echasayo xa isetyenziswe ngokudibeneyo..
2. Le mveliso ayinakusetyenziswa ngokudibeneyo kunyeβ-i-lactone amines kunye ne-fluoroquinolones, kuba le mveliso i-agent ye-bacteriostatic esebenza ngokukhawuleza evimbela i-protein ye-bacterial synthesis, kwaye le yokugqibela i-bactericide esebenza ngokukhawuleza ngexesha lokuzala.Ngaphantsi kwesenzo sangaphambili, i-bacterial protein synthesis iyanqandwa ngokukhawuleza, iibhaktheriya ziyeka ukukhula kunye nokuphindaphinda, kwaye umphumo we-bactericidal wokugqibela uyancipha.Ngoko ke, xa unyango lufuna ukusebenzisa impembelelo yokuvala inzala ngokukhawuleza, ayinakusetyenziswa kunye.
3. Le mveliso ayinakuxutywa ne-sulfadiazine sodium ye-injection ye-intramuscular.Akufanele isetyenziswe ngokudibanisa neziyobisi ze-alkaline xa zilawulwa ngomlomo okanye nge-intramuscularly, ukwenzela ukuba ugweme ukubola kunye nokungaphumeleli.Kwakhona akufanelekanga ukujova nge-intravenous nge-tetracycline hydrochloride, kanamycin, i-adenosine triphosphate, i-coenzyme A, njl., ukuphepha imvula kunye nokunciphisa ukusebenza.
4. Ukuncipha kwemisipha kunye ne-necrosis inokubangelwa emva kwe-injection ye-intramuscular.Ngoko ke, inokuthi ifakwe ngokungafaniyo kwimisipha enzulu yentamo kunye neempundu, kwaye akucebisi ukuphinda i-injection kwindawo enye.
5. Ekubeni le mveliso inokuba ne-embryotoxicity, kufuneka isetyenziswe ngononophelo kwiimazi ezikhulelweyo kunye nezanyisayo.
6. Xa izinga lokushisa lomzimba weehagu ezigulayo liphezulu, linokusetyenziswa kunye ne-antipyretic analgesics kunye ne-dexamethasone, kwaye umphumo ungcono..
7. Ekukhuselweni kunye nokunyangwa kwe-porcine breathing syndrome (PRDC), abanye abantu bancoma ukudibanisa i-florfenicol kunye ne-amoxicillin, i-florfenicol kunye ne-tylosin, kunye ne-florfenicol kunye ne-tylosin, engafanelekanga., ngenxa yokuba kumbono we-pharmacological, ezi zimbini azikwazi ukusetyenziswa ngokudibeneyo.Nangona kunjalo, i-florfenicol ingasetyenziswa kunye ne-tetracyclines efana ne-doxycycline..
8. Le mveliso inetyhefu ye-hematological.Nangona ingayi kubangela i-bone marrow aplastic anemia engenakuguquleka, i-reversible erythropoiesis inhibition ebangelwa yiyo ixhaphake kakhulu kune-chloramphenicol (ikhubazekile).Ichaswa kwixesha lokugonywa okanye izilwanyana ezinobuthathaka obunzima..
9. Ukusetyenziswa kwexesha elide kunokubangela ukuphazamiseka kokutya kunye nokungabikho kwevithamini okanye iimpawu ze-superinfection..
10. Ekukhuseleni kunye nokunyangwa kwezifo zeehagu, kufuneka kuthathwe unonophelo, kwaye isilwanyana kufuneka siqhutywe ngokuhambelana nedosi emiselweyo kunye nekhosi yonyango, kwaye akufanele isetyenziswe kakubi ukuphepha imiphumo emibi..
11. Kwizilwanyana ezinokungasebenzi kakuhle kwezintso, umthamo kufuneka uncitshiswe okanye ixesha lokulawula kufuneka landiswe..
12. Kwimeko yokushisa okuphantsi, kufunyenwe ukuba izinga lokuchithwa licotha;okanye isisombululo esilungisiweyo sinemvula yeflorfenicol, ukufudumeza nje okuncinci (kungekho ngaphezu kwe-45℃), zonke zinokuchithwa ngokukhawuleza.Isisombululo esilungisiweyo sisetyenziswe kakuhle kwiiyure ezingama-48..
Kukhuselekile kakhulu ukusebenzisa ifom yedosi efanelekileyo ngokwentshayelelo engentla kwaye ubhekisele kwidosi ecetyiswayo.Isilwanyana ngasinye sinokufumana ukuphelelwa ngumdla okwexeshana, ukuncitshiswa kwamanzi okanye isifo sohudo, iintlungu ezincinci kwindawo yokutofa kwe-intramuscular kunye nokuphendula kwezicubu ezincinci, zonke ziqhelekileyo kwaye zibuyele kwisiqhelo emva kokuyeka ichiza.
Ixesha lokuposa: Mar-28-2022